ISSN 0300-9092 (Print)
ISSN 2412-5679 (Online)

Применение внеклеточных везикул в эстетической гинекологии

Чернышёв В.С., Хилькевич Е.Г., Колесов Д.В., Аполихина И.А.

1) ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова» Министерства здравоохранения Российской Федерации, Москва, Россия; 2) ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский университет), Москва, Россия; 3) Сколковский институт науки и технологий (Сколтех), Москва, Россия

Внеклеточные везикулы (ВВ), включая экзосомы, – это микроскопические пузырьки, которые выделяются клетками организма. ВВ обладают уникальными физико-химическими свойствами, такими как способность проходить через тканевые барьеры, они часто используются в качестве носителей для доставки терапевтических лекарств в эстетической медицине. В статье приведены литературные данные о механизме регуляции ВВ, их влиянии на ускоренное ремоделирование тканей, подавление рубцевания и гиперпролиферации тканей. Представлены данные о том, каким образом ВВ могут задерживать старение клеток. В настоящее время в эстетической медицине известны 3 исследования, основанные на регистрации клинических испытаний, связанных с заживлением ран. ВВ в основном используют путем местного применения. К преимуществам трансдермальной доставки лекарств относятся: возможность проникать через кутикулу, значительно повышать скорость всасывания активных веществ кожей, снижать эффективную потерю ингредиентов и побочные эффекты, удобство и безопасность.
Заключение: ВВ, как новый тип материала для тканевой инженерии, постепенно начали применяться в эстетической медицине. Однако широкое использование ВВ сталкивается с рядом трудностей. В частности, мало  изучены функции и молекулярный состав ВВ. Остается проблемой высокая стоимость выделения ВВ из биологических жидкостей, а также недостаточно исследована биологическая безопасность аллогенных ВВ. Важным направлением является выбор технологий производства и стандартизации клинических испытаний.

Вклад авторов: Чернышёв В.С., Хилькевич Е.Г., Колесов Д.В., Аполихина И.А. – концепция и дизайн исследования, сбор и обработка материала, подбор литературы по заявленной теме, написание текста, редактирование.
Конфликт интересов: Авторы заявляют об отсутствии конфликта интересов.
Финансирование: Работа выполнена без спонсорской поддержки.
Для цитирования: Чернышёв В.С., Хилькевич Е.Г., Колесов Д.В., Аполихина И.А. 
Применение внеклеточных везикул в эстетической гинекологии.
Акушерство и гинекология. 2026; 2: 31-38
https://dx.doi.org/10.18565/aig.2026.09

Ключевые слова

внеклеточные везикулы
эстетическая гинекология
регенерация ткани
старение клеток

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Поступила 16.01.2026

Принята в печать 10.02.2026

Об авторах / Для корреспонденции

Чернышёв Василий Сергеевич, PhD в химической инженерии, заведующий лабораторией биофотоники, Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова Минздрава России, 117997, Россия, Москва, ул. Ак. Опарина, д. 4; с.н.с. лаборатории «Биофотоника», Сколковский институт науки и технологий, v_chernyshev@oparina4.ru, https://orcid.org/0000-0003-2372-7037
Хилькевич Елена Григорьевна, д.м.н., врач акушер-гинеколог, врач физической и реабилитационной медицины, Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова Минздрава России, 117997, Россия, Москва, ул. Ак. Опарина, д. 4, e_khilkevich@oparina4.ru, https://orcid.org/0000-0001-8826-8439
Колесов Дмитрий Валерьевич, к.ф.-м.н., с.н.с. лаборатории биофотоники, Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова Минздрава России, 117997, Россия, Москва, ул. Ак. Опарина, д. 4, maedros@bk.ru, https://orcid.org/0000-0003-0270-2893
Аполихина Инна Анатольевна, заслуженный врач Российской Федерации, д.м.н., профессор, заведующая отделением эстетической гинекологии и реабилитации, профессор кафедры акушерства и гинекологии департамента профессионального образования, Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова Минздрава России, 117997, Россия, Москва, ул. Ак. Опарина, д. 4; профессор кафедры акушерства, гинекологии, перинатологии и репродуктологии ИПО, Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет); Президент Ассоциации специалистов по эстетической гинекологии (АСЭГ), i_apolikhina@oparina4.ru, https://orcid.org/0000-0002-4581-6295

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