Prognostic value in determining the maternal autoantibodies during pregravid preparation, which affect the development of autism spectrum disorder in a baby

DOI: https://dx.doi.org/10.18565/aig.2017.12.60-66

Torchinov A.M., Tsakhilova S.G., Kuznetsov V.P., Khmelnitskaya A.V., Poletaev A.B.

1 A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow 127473, Delegatskaya str. 20, bld. 1, Russia; 2 Maternity Home Eight, Branch, City Clinical Hospital Sixty-Eight, Moscow 109507, Samarkandskyii bulvar 3, Russia; 3 Immunkulus Medical Research Center, Moscow 105187, Okruzhnoi proezd 30A, Russia; 4 P.K. Anokhin Research Institute of Normal Physiology, Moscow, Russia
Objective. To evaluate the diagnostic and prognostic capabilities of analyzing the profiles of serum immunoreactivity defined by a number of autoantibodies for the identification of women at risk of having a baby with autism spectrum disorder (ASD).
Material and methods. The enzyme immunoassays ELI-Viscero-Test and ELI-Neuro-Test were used to investigate serum from mothers given birth to ASD babies and healthy ones.
Results. The paper describes the most common disorders and complications occurring in the group of women who have given birth to a baby with ASD (a compromised somatic and obstetric/gynecological history), as well as their characteristic changes in the profiles of serum immunoreactivity. It discusses whether there may be a relationship between maternal immunoregulatory disorders and fetal malformations.
Conclusion. The modified production of some maternal IgG autoantibodies that are tropic to antigens of the nervous system and to those of a number of somatic organs (detected by ELI-Viscero-Test and ELI-Neuro-Test) may be a decisive pathogenic factor leading to ASD in her baby.

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Received 09.06.2017

Accepted 23.06.2017


About the Autors


Torchinov Amirhan M., MD, professor, Head of the Department of obstetrics and gynecology, stomatological faculty, A.I. Evdokimov Moscow State University
of Medicine and Dentistry, Ministry of Health of Russia. 127473, Russia, Moscow, Delegatskaya str. 20, bld. 1. Tel.: +79268000600. E-mail: antonina.zanilova@gmail.com
Tcakhilova Svetlana G., MD, professor, Department of obstetrics and gynecology, stomatological faculty, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia; Deputy chief physician for medical part of the Maternity Home Eight, Branch, City Clinical Hospital Sixty-Eight.
109507, Russia, Moscow, Samarkandskyii bulvar 3. Tel.: +79167944730. E-mail: dzh2010@mail.ru
Kuznetsov Vadim P., MD, Deputy chief physician for medical part of the Maternity Home Eight, Branch, City Clinical Hospital Sixty-Eight; Department of obstetrics and gynecology, stomatological faculty, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia.
109507, Russia, Moscow, Samarkandskyii bulvar 3. Tel.: +74957090109. E-mail: rd8@68gkb.ru
Khmelnitskaya Antonina V., Obstetrician-gynecologist, a Maternity Home Eight, Branch, City Clinical Hospital Sixty-Eight; Department of obstetrics and gynecology, stomatological faculty, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia.
109507, Russia, Moscow, Samarkandskyii bulvar 3. Tel.: +79251995090. E-mail: antonina.zanilova@gmail.com
Poletaev Alexandr B., MD, professor, Scientific Director, Immunkulus Medical Research Center; P.K. Anokhin Research Institute of Normal Physiology.
105187 Russia, Moscow, Okruzhnoi proezd 30A. Tel.: +79250811638. E-mail: a-b-poletaev@yandex.ru

For citations: Torchinov A.M., Tsakhilova S.G., Kuznetsov V.P., Khmelnitskaya A.V., Poletaev A.B. Prognostic value in determining the maternal autoantibodies during pregravid preparation, which affect the development of autism spectrum disorder in a baby. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (12): 60-6. (in Russian)
https://dx.doi.org/10.18565/aig.2017.12.60-66


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