Proinflammatory factors of mitochondrial origin in the pathogenesis of recurrent miscarriages and early preterm births

Bulatova Yu.S., Tetruashvili N.K., Vysokikh M.Yu.

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow 117997, Ac. Oparina str. 4, Russia
Objective. To carry out a systematic analysis of the data available in the current literature on the influence of proinflammatory factors of mitochondrial origin (mtDAMPs) in the early stages of gestation.
Material and methods. The paper analyzes the literature data in the past 10 years, by using the search database PubMed.
Results. The review outlines the presented results of studies, which suggest that there are variants of interaction of proinflammatory factors of mitochondrial origin (mtDAMPs) in the pathogenesis of recurrent miscarriage and early preterm labor. It provides evidence for an excessive inflammatory response that prevents normal trophoblast invasion and pregnancy complications
Conclusion. There is a need for further investigations to set up a system for assessing the individual risk of pregnancy losses and for evaluating the effectiveness of treatment, by selecting the most informative inflammatory markers of mitochondrial origin.

Keywords

pregnancy
recurrent miscarriage
premature birth
mitochondria
endothelial dysfunction
inflammation
trophoblast invasion

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Received 03.11.2016

Accepted 11.11.2016

About the Authors

Bulatova Yulia S., Graduate student, Department of Pregnancy Loss Prevention and Therapy, Research Center of Obstetrics, Gynecology and Perinatology,
Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381477. E-mail: yu.bulatova@mail.ru
Tetruashvili Nana K., Doctor of Medicine, Head of the Department of Pregnancy Loss Prevention and Therapy, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381477. E-mail: tetrauly@mail.ru
Vysokikh Mikhail Y., PhD, the head of mitochondrial medicine research group, Research Center of Obstetrics, Gynecology and Perinatology,
Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +7495438-76-33, ext. 1472. E-mail: m_vysokikh@oparina4.ru

For citations: Bulatova Yu.S., Tetruashvili N.K., Vysokikh M.Yu. Proinflammatory factors of mitochondrial origin in the pathogenesis of recurrent miscarriages and early preterm births. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (8): 5-9. (in Russian)
http://dx.doi.org/10.18565/aig.2017.8.5-9

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