Cesarean scar pregnancy. Current state of the problem. Diagnostics. Clinical symptoms. Medical tactics

Tskhay V.B., Vergunov N.A., Yametov P.K.

Department of Perinatology, Obstetrics and Gynecology, Prof. V.F. Voino-Yasenetsky Krasnoyarsk Medical University, Ministry of Health of Russia, Krasnoyarsk 660022, Partizana Zheleznyaka str. 1, Russia
Objective. To carry out a systematic analysis of the data which is available in modern literature, concerning prevalence, etiology, pathogenesis, diagnostics and treatment of cesarean scar pregnancy (CSP) and possible complications.
Subject and methods. The review included foreign and Russian publications which entered the Pub med database on this subject. Length of search covered 15 years.
Results. Modern data on prevalence, etiology and pathogenesis of CSP are submitted. Value of risk factors is reflected in the development of CSP and its complications. Value of transvaginal scanning in combination with dopplerometry is specified at early diagnostics of BRM as rather reliable method. Efficiency and low number of complications at the use of combined treatment methods is demonstrated: systemic application of Methotrexate, carrying out a laparoscopy together with a hysteroresektoskopy.
Conclusion. Frequency of CSP grows together with the frequency of operation of Cesarean section. The effective organosafe treatment provides fertility, and decreases a number of serious complications and critical situations perhaps only at timely diagnostics on early term of gestation. The comparative assessment of efficiency of the combined surgical and medication treatment is presented in separate publications. However, almost total absence of information on CSP in domestic special literature, absence of uniform algorithm of diagnostics and treatment, can lead to mistakes of obstetricians-gynecologists both in diagnostics, and in tactics of maintaining pregnant women with this pathology.

Keywords

Кеу words: cesarean section
methotrexate
caesarean scar pregnancy
ectopic pregnancy

References

1. Ash A., Smith A., Maxwell D. Caesarean scar pregnancy. BJOG. 2007; 114(3): 253-63.

2. Birge Ö., Karaca C., Arslan D., Kinali E. Medical management of cesarean scar pregnancy at advanced age: case report and literature review. Clin. Exp. Obstet. Gynecol. 2016; 43(1): 140-2.

3. Seow K.M., HuangL.W., Lin Y.H., LinM.Y., Tsai Y.L., Hwang J.L. Cesarean scar pregnancy: issues in management. Ultrasound Obstet. Gynecol. 2004; 23(3): 247-53.

4. Kanat-Pektas M., Bodur S., Dundar O., Bakır V.L. Systematic review: What is the best first-line approach for cesarean section ectopic pregnancy? Taiwan. J. Obstet. Gynecol. 2016; 55(2): 263-9.

5. Liu H., Leng J., Shi H., Lang J. Expectant treatment of cesarean scar pregnancy: two case reports and a glimpse at the natural courses. Arch. Gynecol. Obstet. 2010; 282(4): 455-8.

6. Morgan-Ortiz F., Retes-Angulo B., Retes-Lapizco B., Morgan-Ruiz F.V. Repeated ectopic pregnancy in previous caesarean scar: a case report and literature review. Ginecol. Obstet. Mex. 2015; 83(10): 641-7.

7. Sidorov A.E., Sidorov E.S., Samoylova A.V., Gunin A.G., Deripasko T.V., Chernyishov V.V., Prokopev I.I., Mayorov V.S. Pregnancy in the uterine scar after cesarean section. Zdravoohranenie Chuvashii. 2014; 3(39): 49-56. (in Russian)

8. Manukhina T.B., Pomortsev A.V. Features of ultrasonic diagnosis and treatment policy in the management of patients with pregnancy in the rumen after cesarean section. Rossiyskiy elektronnyiy zhurnal luchevoy diagnostiki. 2012; 2(3): 95-9. (in Russian)

9. Sarkisov S.E., Romanovskaya O.A., Demidov A.V., Belousov D.M. The use of ultrasound for the diagnosis of pregnancy in the uterine scar after cesarean section. Ultrazvukovaya i funktsionalnaya diagnostika. 2009; 2: 36-42. (in Russian)

10. Chen Z.Y., Zhang X.M., Xu H., Zhang J, Huang X.F. Management of cesarean scar pregnancy by hysteroscopy combined with uterine artery embolism. Zhonghua Fu Chan Ke Za Zhi. 2011; 46(8): 591-4.

11. Zhang B., Jiang Z.B., Huang M.S., Guan S.H., Zhu K.S., Qian J.S. Uterine artery embolization combined with methotrexate in the treatment of cesarean scarpregnancy: results of a case series and review of the literature. J. Vasc. Interv. Radiol. 2012; 23(12): 1582-8.

12. Liang Z., Su J., Yang H. Feasibility of treatment of cesarean scar pregnancy with dilatation and curettage under ultrasound guidance. Zhonghua Yi Xue Za Zhi. 2015; 95(37): 3045-9.

13. Gao L., Huang Z., Zhang X., Zhou N., Huang X., Wang X. Reproductive outcomes following cesarean scar pregnancy – a case series and review of the literature. Eur. J. Obstet. Gynecol. Reprod. Biol. 2016; 200: 102-7.

14. Liu X., Lynch C.D., Cheng W.W., Landon M.B. Lowering the highrate of caesarean delivery in China: an experience from Shanghai. BJOG. 2016; 123(10): 1620-8. doi: 10.1111/1471-0528.14057.

15. Nawroth F., Foth D., Wilhelm L., Schmidt T., Warm M., Römer T. Conservative treatment of ectopic pregnancy in a cesarean section scar with methotrexate: a case report. Eur. J. Obstet. Gynecol. Reprod. Biol. 2001; 99(1): 135-7.

16. Ramphal S.R., Moodley J. Antepartum uterine rupture in previous caesarean sections presenting as advanced extrauterine pregnancies: lessons learnt. Eur. J. Obstet. Gynecol. Reprod. Biol. 2009; 143(1): 3-8.

17. Tzankova M., Nikolov A., Pirnareva E. Uterine scar after caeserean section- predicting the risk of uterine rupture and decision on the way of delivery. Akush. Ginekol. (Sofiia). 2014; 53(4): 29-32.

18. Tsai S.W., Huang K.H., Ou Y.C., Hsu T.Y., Wang C.B., Chang M.S. et al. . Low-lying-implantation ectopic pregnancy: a cluster of cesareanscar, cervico-isthmus, and cervical ectopic pregnancies in the first trimester. Taiwan. J. Obstet. Gynecol. 2013; 52(4): 505-11.

19. Qian Z.D., Guo Q.Y., Huang L.L. Identifying risk factors for recurrent cesarean scar pregnancy: a case-control study. Fertil. Steril. 2014; 102(1): 129-34.

20. Fylstra D.L. Ectopic pregnancy not within the (distal) fallopian tube: etiology, diagnosis, and treatment. Am. J. Obstet. Gynecol. 2012; 206 (4): 289-99.

21. Osborn D.A., Williams T.R., Craig B.M. Cesarean scar pregnancy: sonographic and magnetic resonance imaging findings, complications, and treatment. J. Ultrasound Med. 2012; 31(9): 1449-56.

22. Ouyang Y., Li X., Yi Y., Gong F., Lin G., Lu G. First-trimester diagnosis and management of Cesareanscar pregnancies after in vitro fertilization-embryo transfer: a retrospective clinical analysis of 12 cases. Reprod. Biol. Endocrinol. 2015; 13: 126.

23. Maymon R., Halperin R., Mendlovic S., Schneider D., Vaknin Z., Herman A. et al. Ectopic pregnancies in Caesarean section scars: the 8 year experience of one medical centre. Hum. Reprod. 2004; 19(2): 278-84.

24. Weimin W., Wenqing L. Effect of early pregnancy on a previous lower segment cesarean section scar. Int. J.Gynaecol. Obstet. 2002;77(3): 201-7.

25. Sadeghi H., Rutherford T., Rackow B.W., Campbell K.H., Duzyj C.M., Guess M.K. et al. Cesarean scar ectopic pregnancy: case series and review of the literature. Am. J. Perinatol. 2010; 27(2): 111-20.

26. Rotas M.A., Haberman S., Levgur M. Cesarean scar ectopic pregnancies: etiology, diagnosis, and management. Obstet. Gynecol. 2006; 107(6): 1373-81.

27. Yin L., Tao X., Zhu Y.C., Yu X.L., Zou Y.H., Yang H.X. Cesarean scar pregnancy analysis of 42 cases. Zhonghua Fu Chan Ke Za Zhi. 2009;44(8): 566-9.

28. Chiang A.J., La V., Chou C.P., Wang P.H., Yu K.J. Ectopic pregnancy in a cesarean section scar. Fertil. Steril. 2011; 95(7): 2388-9.

29. Timor-Tritsch I.E., Monteagudo A. Unforeseen consequences of the increasing rate of cesarean deliveries: early placenta accreta and cesarean scar pregnancy. A review. Am. J. Obstet. Gynecol. 2012; 207(1): 14-29.

30. Yu X.L., Zhang N., Zuo W.L. Cesarean scar pregnancy: an analysis of 100 cases. Zhonghua Yi Xue Za Zhi. 2011; 91(45): 3186-9.

31. Rajakumar C., Agarwal S., Khalil H., Fung Kee Fung K.M., Shenassa H., Singh S.S. Caesarean scar pregnancy. J. Obstet. Gynaecol. Can. 2015; 37(3): 199-200.

32. Michaels A.Y., Washburn E.E., Pocius K.D., Benson C.B., Doubilet P.M., Carusi D.A. Outcome of cesarean scar pregnancies diagnosed sonographically in the first trimester. J. Ultrasound Med. 2015;34(4): 595-9.

33. Acar T., Sahin A.C., SemizI., Gulac B. Cesarean scar pregnancy: role of serial transabdominal ultrasonography in the diagnosis and treatment response following dilation and curettage. Med. Ultrason. 2016;18(1): 135-6.

34. Moschos E., Wells C.E., Twickler D.M. Biometric sonographic findings of abnormally adherent trophoblastic implantations on cesarean delivery scars. J. Ultrasound Med. 2014; 33(3): 475-81.

35. Qi F., Zhou W., Wang M.F., Chai Z.Y., Zheng L.Z. Uterine artery embolization with and without local methotrexate infusion for the treatment of cesarean scar pregnancy. Taiwan. J. Obstet. Gynecol. 2015; 54(4): 376-80.

36. Rheinboldt M., Osborn D., Delproposto Z. Cesarean section scarectopic pregnancy: a clinical case series. J. Ultrasound. 2015; 18(2): 191-5.

37. Overcash R.T., Khackician Z.H. Late-firs trimester cesarean section scar ectopic pregnancy with placenta increta: a case report. J. Reprod. Med. 2012; 57(1-2): 61-4.

38. Ben N.J., Ofili-Yebovi D., Marsh M., Jurkovic D. First-trimester cesarean scar pregnancy evolving into placenta previa/accreta at term. J. Ultrasound Med. 2012; 31(9): 1449-56.

39. Lam P.M., Lo K.W., Lau T.K. Unsuccessful medical treatment of cesarean scar ectopic pregnancy with systemic methotrexate: a report of two cases. Acta Obstet. Gynecol. Scand. 2004; 83(1): 108-11.

40. Muraji M., Mabuchi S., Hisamoto K., Muranishi M., Kanagawa T., Nishio Y. et al. Cesarean scar pregnancies successfully treated with methotrexate. Acta Obstet. Gynecol. Scand. 2009;88(6): 720-3.

41. Bayoglu T.Y., Mete U.U., Balik G., Ustuner I., Kir S.F., Güvendağ G.E.S. Management of cesarean scar pregnancy with suction curettage: a report of four cases and review of the literature. Arch. Gynecol. Obstet. 2014;289(6): 1171-5.

42. Arslan M., Pata O., Dilek T.U., Aktas A., Aban M., Dilek S. Treatment of viable cesarean scar ectopic pregnancy with suction curettage. Int. J. Gynaecol. Obstet. 2005; 89(2): 163-6.

43. Jurkovic D., Knez J., Appiah A., Farahani L., Mavrelos D., Ross J.A. Surgical treatment of Cesarean scar ectopic pregnancy: efficacy and safety of ultrasound-guided suction curettage. Ultrasound Obstet. Gynecol. 2016;47(4): 511-7.

44. Wu X., Zhang X., Zhu J., Di W. Caesarean scar pregnancy: comparative efficacy and safety of treatment by uterine artery chemo embolization and systemic methotrexate injection. Eur. J. Obstet. Gynecol. Reprod. Biol. 2012;161(1): 75-9.

45. He Y., Wu X., Zhu Q., Wu X., Feng L., Wu X. et al. Combined laparoscopy and hysteroscopy vs. uterine curettage in the uterine artery embolization-based management of cesarean scar pregnancy: a retrospective cohort study. BMC Womens Health. 2014; 14: 116.

46. Wang G., Liu X., Bi F., Yin L., Sa R., Wang D., Yang Q. Evaluation of the efficacy of laparoscopic resection for the management of exogenous cesarean scar pregnancy. Fertil. Steril. 2014; 101(5): 1501-7.

47. Api M., Boza A., Gorgen H., Api O. Should cesarean scar defect be treated laparoscopically? A case report and review of the literature. J. Minim. Invasive Gynecol. 2015; 22(7): 1145-52.

48. Deb S., Clewes J., Hewer C., Raine-Fenning N. The management of Cesarean scar ectopic pregnancy following treatment with methotrexate — a clinical challenge. Ultrasound Obstet. Gynecol. 2007; 30(6): 889-92.

49. Wu X., Xue X., Wu X., Lin R., Yuan Y., Wang Q. et al. Combined laparoscopy and hysteroscopy vs. uterine curettage in the uterine artery embolization-based management of cesarean scar pregnancy: a cohort study. Int. J. Clin. Exp. Med. 2014; 7(9): 2793-803.

50. Robinson J.K., Dayal M.B., Gindoff P., Frankfurter D. A novel surgical treatment for cesarean scar pregnancy: laparoscopically assisted operative hysteroscopy. Fertil. Steril. 2009; 92(4): 1497. e13-6.

51. Birch P.K., Hoffmann E., Rifbjerg L.C., Nielsen H.S. Cesarean scar pregnancy: a systematic review of treatment studies. Fertil. Steril. 2016; 105(4): 958-67.

Received 16.08.2016

Accepted 02.09.2016

About the Authors

Vitaly B. Tskhay, MD, prof., head of the Department of perinatology, obstetrics and gynecology, Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University.
660022, Russia, Krasnoyarsk, Partizana Zheleznyaka str. 1. Tel.: +79232872134. E-mail: tchai@yandex.ru
Pavel K. Yametov, assistant of the Department of perinatology, obstetrics and gynecology, Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University.
660022, Russia, Krasnoyarsk, Partizana Zheleznyaka str. 1. Tel.: +79509782527. E-mail: mail.rur@mail.ru
Nikita A. Vergunov, postgraduater of the Department of perinatology, obstetrics and gynecology, Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University.
660022, Russia, Krasnoyarsk, Partizana Zheleznyaka str. 1. Tel.: +79676124502. E-mail: vergunov.n@gmail.com

For citations: Tskhay V.B., Vergunov N.A., Yametov P.K. Cesarean scar pregnancy.
Current state of the problem. Diagnostics. Clinical symptoms. Medical tactics.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (3): 5-10. (in Russian)
http://dx.doi.org/10.18565/aig.2017.3.5-10

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