Патофизиологические механизмы развития акушерского антифосфолипидного синдрома

Менжинская И.В., Ванько Л.В.

ФГБУ Научный центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова Минздрава России, Москва
Цель исследования. Проанализировать данные современной научной литературы о возможных патофизиологических механизмах развития акушерского антифосфолипидного синдрома (АФС), подтвержденных результатами экспериментов in vitro и in vivo и гистопатологических исследований.
Материал и методы. Включены данные зарубежных и отечественных статей по теме исследования, найденных в Pubmed и eLIBRARY и опубликованных за последние 20 лет.
Результаты. Так как тромботические события не могут объяснить все акушерские проявления АФС, предполагаются другие патофизиологические механизмы, ассоциированные с прямым воздействием антифосфолипидных антител на развитие и функционирование плаценты и ее воспалением, опосредованным комплементом.
Заключение. Понимание патогенетических механизмов расширяет возможности применения таргетной терапии у пациенток с АФС, особенно резистентных к традиционной терапии.

Ключевые слова

акушерский антифосфолипидный синдром
антифосфолипидные антитела
патофизиологические механизмы
таргетная терапия

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Поступила 21.03.2017

Принята в печать 28.04.2017

Об авторах / Для корреспонденции

Менжинская Ирина Владимировна, к.м.н., старший научный сотрудник лаборатории клинической иммунологии ФГБУ НЦАГиП им. академика В.И. Кулакова
Минздрава России. Адрес: 117997, Россия, Москва, ул. Академика Опарина, д. 4. Телефон: 8 (915) 345-06-59. E-mail: i_menzinskaya@oparina4.ru
Ванько Людмила Викторовна, д.м.н., профессор, ведущий научный сотрудник лаборатории клинической иммунологии ФГБУ НЦАГиП им. академика В.И. Кулакова Минздрава России. Адрес: 117997, Россия, Москва, ул. Академика Опарина, д. 4. Телефон: 8 (915) 305-34-32. E-mail: LVanko@oparina4.ru

Для цитирования: Менжинская И.В., Ванько Л.В. Патофизиологические механизмы развития акушерского антифосфолипидного синдрома.
Акушерство и гинекология. 2018; 1: 5-12.
https://dx.doi.org/10.18565/aig.2018.1.5-12

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