Effects of anthropogenic chemicals on reproduction

Syrkasheva A.G., Dolgushina N.V., Yarotskaya E.L.

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow 117997, Ac. Oparina str. 4, Russia
Objective. To carry out a systematic analysis of the data available in the current literature on the effects of some anthropogenic chemicals on human fertility, including on the effectiveness of assisted reproductive technology programs.
Material and methods. The review includes the articles by foreign and Russian authors on this topic, which have been published in the Pubmed journals in the past 10 years.
Results. The authors analyze the literature data on the effects of heavy metals, phthalates, and bisphenol A on various aspects of human reproductive function. They present data on the possible pathogenetic mechanisms of action of anthropogenic chemicals on the quality of gametes and the efficiency of treatment for infertility.
Conclusion. It is necessary to further study the molecular mechanisms of negative action of toxicants on human fertility in order to determine management tactics in infertility patients.

Keywords

infertility
in vitro fertilization
reproductive toxicants
heavy metals
bisphenol A
phthalates

References

1. Долгушина Н.В., Ратушняк С.С., Сокур С.А., Глинкина Ж.И., Калинина Е.А. Риск анеуплоидии эмбрионов в программах вспомогательных репродуктивных технологий у мужчин с патозооспермией (мета-анализ). Акушерство и гинекология. 2012; 7: 4-13. [Dolgushina N.V., Ratushnyak S.S., Sokur S.A., Glinkina Zh.I. Risk for embryonic aneuploidy in assisted reproductive technology programs for men with abnormal zoospermia: Meta-analysis. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2012; 7: 4-13. (in Russian)]

2. Magli M.C., Montag M., Kster M., Muzi L., Geraedts J., Collins J. et al. Polar body array CGH for prediction of the status of the corresponding oocyte. Part II: Technical aspects. Hum. Reprod. 2011; 26(11): 3181-5.

3. Казанцева Е., Долгушина Н.В., Ильченко И.Н. Влияние антропогенных химических веществ на течение беременности. Акушерство и гинекология. 2013; 2: 18-23. [Kazantseva E.V., Dolgushina N.V., Ilchenko I.N. Effect of anthropogenic chemicals on the course of pregnancy. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2013; 2: 18-23. (in Russian)]

4. Долгушина Н.В., Казанцева Е., Пивоварова Л.В. Влияние антропогенных химических веществ на массу тела новорожденных. Акушерство и гинекология. 2013; 12: 58-64. [Dolgushina N.V., Kazantseva E.V., Pivovarova L.V. Effect of anthropogenic chemical substances on neonatal weight. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2013; 12: 58-64. (in Russian)]

5. Всемирная организация здравоохранения. Окружающая среда и социальные детерминанты здоровья. Женева; 2017. [World Health Organization. The environment and the social determinants of health. Geneva; 2017. (in Russian)]

6. Du Y., Fang Y., Wang Y., Zeng Q., Guo N., Zhao H. Follicular fluid and urinary concentrations of phthalate metabolites among infertile women and associations with in vitro fertilization parameters. Reprod. Toxicol. 2016; 61: 142-50. http://dx.doi.org/10.1016/j.reprotox.2016.04.005

7. Ziv-gal A., Flaws J.A. Evidence for bisphenol A-induced female infertility: a review (2007-2016). Fertil. Steril. 2016; 106(4): 827-56. http://dx.doi.org/10.1016/j.fertnstert.2016.06.027

8. Bloom M.S., Fujimoto V.Y., Steuerwald A.J., Cheng G., Browne R.W., Parsons P.J. Background exposure to toxic metals in women adversely influences pregnancy during in vitro fertilization ( IVF ). Reprod. Toxicol. 2012; 34(3): 471-81. http://dx.doi.org/10.1016/j.reprotox.2012.06.002

9. Agarwal A., Aponte-mellado A., Premkumar B.J., Shaman A., Gupta S. The effects of oxidative stress on female reproduction : a review. Reprod. Biol. Endocrinol. 2012; 10: 49.

10. Wright D.L., Afeiche M.C., Ehrlich S., Smith K., Paige L., Chavarro J.E. et al. Hair mercury concentrations and in vitro fertilization (IVF) outcomes among women from a fertility clinic. Reprod. Toxicol. 2015; 51: 125-32.

11. Zhou Y., Fu X., He D., Zou X., Wu C. Evaluation of urinary metal concentrations and sperm DNA damage in infertile men from an infertility clinic. Environ. Toxicol. Pharmacol. 2016; 45: 68-73. http://dx.doi.org/10.1016/j.etap.2016.05.020

12. Tanrikut E., Karaer A., Celik O., Celik E., Otlu B., Yilmaz E. et al. Role of endometrial concentrations of heavy metals (cadmium, lead, mercury and arsenic) in the aetiology of unexplained infertility. Eur. J. Obstet. Gynecol. Reprod. Biol. 2014; 179: 187-90.

13. Johnstone E., Germaine M., Buck Louis P., Steuerwald A., Palmerc C., Chen Z. et al. Increased urinary cobalt and whole blood concentrations of cadmium and lead in women with uterine leiomyomata: Findings from the ENDO Study. Reprod. Toxicol. 2014; 49: 27-32.

14. Zeng Q., Zhou B., Feng W., Wang Y., Liu A., Yue J. et al. Associations of urinary metal concentrations and circulating testosterone in Chinese men. Reprod. Toxicol. 2013; 41: 109-14. http://dx.doi.org/10.1016/j.reprotox.2013.06.062

15. Li C.J., Yeh C.Y., Chen R.Y., Tzeng C.R., Han B.C., Chien L.C. Biomonitoring of blood heavy metals and reproductive hormone level related to low semen quality. J. Hazard. Mater. 2015; 300: 815-22. http://dx.doi.org/10.1016/j.jhazmat.2015.08.027

16. Agarwal A., Majzoub A., Esteves S.C., Ko E., Ramasamy R., Zini A. Clinical utility of sperm DNA fragmentation testing : practice recommendations based on clinical scenarios. Transl. Androl. Urol. 2016; 5(6): 935-50.

17. Martínez-soto J.C., Domingo J.C., Cordobilla B., Fernández L., Albero P., Gadea J. et al. Dietary supplementation with docosahexaenoic acid (DHA) improves seminal antioxidant status and decreases sperm DNA fragmentation. Syst. Biol. Reprod. Med. 2016; 62(6): 387-95. http://dx.doi.org/10.1080/19396368.2016.1246623

18. Ehrlich S., Williams P.L., Missmer S.A., Flaws J.A., Ye X., Calafat A.M. et al. Urinary bisphenol A concentrations and early reproductive health outcomes among women undergoing IVF. Hum. Reprod. 2012; 27(12): 3583-92.

19. Gaskins A.J., Chiu Y., Mı L., Williams P.L., Ehrlich S., Chavarro J.E. et al. Urinary bisphenol A concentrations and association with in vitro fertilization outcomes among women from a fertility clinic. Hum. Reprod. 2015; 30(9): 2120-8.

20. Ehrlich S., Williams P., Missmer S., Flaws J., Berry K., Calafat A. et al. Urinary bisphenol A concentrations and implantation failure among women undergoing in vitro fertilization. Environ. Health Perspect. 2012; 120(7):978-83.

21. Lassen T.H., Frederiksen H., Jensen T.K., Petersen J.H., Joensen U.N. Urinary bisphenol A levels in young men: association with reproductive hormones and semen quality. Environ. Health Perspect. 2014; 122(5): 478-84.

22. Vitku J., Sosvorova L., Chlupacova T., Hampl R., Hill M., Sobotka V. Differences in bisphenol A and estrogen levels in the plasma and seminal plasma of men with different degrees of infertility. Physiol. Res. 2015; 64(Suppl. 2): S303-11.

23. Yin L., Dai Y., Cui Z., Jiang X., Liu W., Han F. et al. The regulation of cellular apoptosis by the ROS-triggered PERK/EIF2α/chop pathway plays a vital role in bisphenol A-induced male reproductive toxicity. Toxicol. Appl. Pharmacol. 2017; 314: 98-108.

24. Yang C., Zhang D., Song Z., Hou Y., Bao Y., Sun L.G. Protumoral TSP50 regulates macrophage activities and polarization via production of TNF-α and IL-1β, and activation of the NF-κB signaling pathway. PLoS One. 2015; 10(12): e 0145095.

25. Dobrzyńska M.M. Phthalates - widespread occurrence and the effect on male gametes. Part 2. The effects of phthalates on male gametes. Rocz. Panstw. Zakl. Hig. 2016; 67(3): 209-21.

26. Dodge L., Williams P., Williams M., Missmer S., Souter I., Calafat A. et al. Associations between paternal urinary phthalate metabolite concentrations and reproductive outcomes among couples seeking fertility treatment. Reprod. Toxicol. 2015; 58: 184-93.

27. Messerlian C., Souter I., Gaskins A.J., Williams P.L., Ford J.B., Chiu Y. et al. Urinary phthalate metabolites and ovarian reserve among women seeking infertility care. Hum. Reprod. 2016; 31(1): 75-83.

28. Messerlian C., Wylie B.J., Minguez-alarcon L., Williams P.L., Ford J.B., Souter I.C. et al. Urinary concentrations of phthalate metabolites and pregnancy loss among women conceiving with medically assisted reproduction. Epidemiology. 2016; 27(6): 879-88.

29. Adir M., Combelles C., Mansur A., Ophir L., Hourvitz A., Orvieto R. et al. Dibutyl phthalate impairs steroidogenesis and a subset of LH-dependent genes in cultured human mural granulosa cell in vitro. Reprod. Toxicol. 2017;69: 13-8.

30. Collins J.J., Ness R., Tyl R.W., Krivanek N., Esmen N.A., Hall T.A. A review of adverse pregnancy outcomes and formaldehyde exposure in human and animal studies. Regul. Toxicol. Pharmacol. 2001; 34(1): 17-34.

31. Wang L.S., Wang L., Wang L., Wang G., Li Z.H., Wang J.J. Effect of 1-butyl-3-methylimidazolium tetrafluoroborate on the wheat (Triticum aestivum L.) seedlings. Environ. Toxicol. 2009; 24(3): 296-303.

32. Naghdi M., Maghbool M., Seifalah-Zade M., Mahaldashtian M., Makoolati Z., Kouhpayeh S.A. et al. Effects of common fig (Ficus carica) leaf extracts on sperm parameters and testis of mice intoxicated with formaldehyde. Evid. Based Complement Alternat. Med. 2016; 2016: 2539127.

33. WHO/UNEP. State of the science of endocrine disrupting chemicals - 2012. An assessment of the state of the science of endocrine disruptors prepared by a group of experts for the United Nations Environment Programme (UNEP) and WHO. World Health Organization; 2013. 296p.

34. Neal M.S., Zhu J., Foster W.G. Quantification of benzo[a]pyrene and other PAHs in the serum and follicular fluid of smokers versus non-smokers. Reprod. Toxicol. 2008; 25(1): 100-6.

35. Perrin J., Tassistro V., Mandon M., Grillo J.M., Botta A., Sari-Minodier I. Tobacco consumption and benzo(a)pyrene-diol-epoxide-DNA adducts in spermatozoa: in smokers, swim-up procedure selects spermatozoa with decreased DNA damage. Fertil. Steril. 2011; 95(6): 2013-7. http://dx.doi.org/10.1016/j.fertnstert.2011.02.021

36. Ling X., Zhang G., Chen Q., Yang H., Sun L., Zhou N. et al. Shorter sperm telomere length in association with exposure to polycyclic aromatic hydrocarbons: Results from the MARHCS cohort study in Chongqing, China and in vivo animal experiments. Environ. Int. 2016; 95: 79-85. http://dx.doi.org/10.1016/j.envint.2016.08.001

37. Rosemond Z., Chou S., Wilson J., Schwartz M., Tomei-Torres F., Ingerman L. et al. Toxicological profile for styrene. U.S. Department of health and human services, Public Health Service, Agency for Toxic Substances and Disease Registry; 2010. 283p. http://www.atsdr.cdc.gov/toxprofiles/tp53.pdf

38. Naccarati A., Zanello A., Landi S., Consigli R., Migliore L. Sperm-FISH analysis and human monitoring: A study on workers occupationally exposed to styrene. Mutat. Res. 2003; 537(2): 131-40.

39. Migliore L., Naccarati A., Zanello A., Scarpato R., Bramanti L., Mariani M. Assessment of sperm DNA integrity in workers exposed to styrene. Hum. Reprod. 2002; 17(11): 2912-8.

40. Казанцева Е., Долгушина Н.В., Донников А.Е., Беднягин Л.А., Баранова Е.Е., Терешков П.П. Влияние пренатальной экспозиции бенз(а)пирена, стирола и формальдегида на массу тела при рождении в зависимости от полиморфизмов генов системы детоксикации. Акушерство и гинекология. 2016; 7: 68-78. http://dx.doi.org/10.18565/aig.2016.7.68-78 [Kazantseva E.V., Dolgushina N.V., Donnikov A.E., Bednyagin L.A., Baranova E.E., Tereshkov P.P. Impact of prenatal exposure to benz[a]pyrene, styrene, and formaldehyde on birth weight in relation to detoxification system gene. Akusherstvo i ginekologiya/Obstetrics and Gynecology. 2016; (7): 68-78. (in Russian). http://dx.doi.org/10.18565/aig.2016.7.68-78]

Received 17.05.2017

Accepted 23.06.2017

About the Authors

Syrkasheva Anastasia Grigorievna, M.D., Ph.D., Researcher of the IVF Department, Research Center of Obstetrics, Gynecology and Perinatology,
Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: a_syrkasheva@oparina4.ru
Dolgushina Nataliya Vitalievna, M.D., Ph.D., M.P.H., Head of R&D Department, Research Center of Obstetrics, Gynecology and Perinatology,
Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954384977. E-mail: n_dolgushina@oparina4.ru
Yarotskaya Ekaterina Lvovna, M.D., Ph.D., Head of the Department for International Cooperation, Research Center of Obstetrics, Gynecology and Perinatology,
Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381166. E-mail: e_yarotskaya@oparina4.ru

For citations: Syrkasheva A.G., Dolgushina N.V., Yarotskaya E.L.
Effects of anthropogenic chemicals on reproduction.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (3): 16-21. (in Russian)
https://dx.doi.org/10.18565/aig.2018.3.16-21

Similar Articles

By continuing to use our site, you consent to the processing of cookies that ensure the proper functioning of the site.