Association of antibodies against gonadotropins and female sex hormones with reproductive disorders


Menzhinskaya I.V., Vanko L.V.

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow 117997, Ac. Oparina str. 4, Russia
Objective. To analyze the data of current research literature on the role of antibodies against gonadotropins and female sex hormones in reproductive disorders in women.
Material and methods. The review includes data of foreign and national articles on the research topic found in Pubmed and eLIBRARY and published in the last 20 years.
Results. According to scientific publications the production of antibodies against gonadotropins is induced by the use of hormonal drugs or contraceptive vaccines, and can also occur spontaneously in women with infertility and recurrent pregnancy loss. The effect of antibodies is associated with their ability to neutralize the biological activity of the hormone. Enzyme-linked immunosorbent assay is most commonly used for the detection of antibodies in blood, and intradermal testing is employed for diagnosis of hypersensitivity to female sex hormones. Antibodies against gonadotropins and female sex hormones are considered as possible risk factors for infertility, IVF failure and pregnancy loss.
Conclusion. Early detection of antibodies or hypersensitivity to the hormones and carrying out appropriate treatment and preventive measures can increase the treatment efficacy of infertility and improve outcomes of pregnancy in women with recurrent abortion.


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Received 29.11.2016

Accepted 23.12.2016

About the Autors

Menzhinskaya Irina Vladimirovna, Ph.D., Senior Researcher, Laboratory of Clinical Immunology, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79153450659. E-mail:
Vanko Lyudmila Viktorovna, MD, Professor, Leading Researcher, Laboratory of Clinical Immunology, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79153053432. E-mail:

For citations: Menzhinskaya I.V., Vanko L.V. Association of antibodies
against gonadotropins and female sex hormones with reproductive disorders.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (9): 20-7. (in Russian)

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