Онкологические аспекты полипов эндометрия в пери- и постменопаузе

1. Uglietti A., Buggio L., Farella M., Chiaffarino F., Dridi D., Vercellini Р. The risk of malignancy in uterine polyps: A systematic review and meta-analysis. Eur. J. Obstet. Gynecol. Reprod. Biol. 2019; 237: 48-56. https://dx.doi.org/10.1016/j.ejogrb.2019.04.009
2. Al-Rayes S., Mohamed M., Suarthana E., Kigloo H.N., Raina J., Tulandi T. Risks of malignancy among 11,204 patients with endometrial polyp: a systematic review and meta-analysis. Gynecol. Minim. Invasive Ther. 2025; 14(1): 40-50. https://dx.doi.org/10.4103/gmit.GMIT-D-24-00056
3. Clarke M.A., Long B.J., Del Mar Morillo A., Arbyn M, Bakkum-Gamez J.N., Wentzensen N. Association of endometrial cancer risk with postmenopausal bleeding in women: a systematic review and meta-analysis. JAMA Intern. Med. 2018; 178(9): 1210-22. https://dx.doi.org/10.1001/jamainternmed.2018.2820
4. Patrizi L., Ticconi C., Borelli B., Finocchiaro S., Chiaramonte C., Sesti F. et al. Clinical significance of endometrial abnormalities: an observational study on 1020 women undergoing hysteroscopic surgery. BMC Womens Health. 2022; 22(1): 106. https://dx.doi.org/10.1186/s12905-022-01682-5
5. Salim S., Won H., Nesbitt-Hawes E., Campbell N., Abbott J. Diagnosis and management of endometrial polyps: a critical review of the literature. J. Minim. Invasive Gynecol. 2011; 18(5): 569-81. https://dx.doi.org/10.1016/j.jmig.2011.05.018
6. Ferrazzi E., Zupi E., Leone F.P., Savelli L., Omodei U., Moscarini M. et al. How often are endometrial polyps malignant in asymptomatic postmenopausal women? A multicenter study. Am. J. Obstet. Gynecol. 2009; 200(3): 235.e1-6. https://dx.doi.org/10.1016/j.ajog.2008.09.876
7. Асатурова А.В., Чернуха Г.Е., Иванов И.А., Куземин А.А. Клинико-морфометрические особенности полипов эндометрия и механизмы возникновения аномальных маточных кровотечений. Акушерство и гинекология. 2019; 7: 64-70.
8. Munro M.G., Critchley H.O., Broder M.S., Fraser I.S.; FIGO Working Group on Menstrual Disorders. FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age. Int. J. Gynaecol. Obstet. 2011; 113(1): 3-13. https://dx.doi.org/10.1016/j.ijgo.2010.11.011
9. Clark T.J., Stevenson H. Endometrial polyps and abnormal uterine bleeding (AUB-P): what is the relationship, how are they diagnosed and how are they treated? Best Pract. Res. Clin. Obstet. Gynaecol. 2017; 40: 89-104. https://dx.doi.org/10.1016/j.bpobgyn.2016.09.005
10. Van Den Bosch T., Verbakel J.Y., Valentin L., Wynants L., De Cock B., Pascual M.A. et al. Typical ultrasound features of various endometrial pathologies described using International Endometrial Tumor Analysis (IETA) terminology in women with abnormal uterine bleeding. Ultrasound Obstet. Gynecol. 2021; 57(1): 164-72. https://dx.doi.org/10.1002/uog.22109
11. Kaveh M., Sadegi K., Salarzaei M., Parooei F. Comparison of diagnostic accuracy of saline infusion sonohysterography, transvaginal sonography, and hysteroscopy in evaluating the endometrial polyps in women with abnormal uterine bleeding: a systematic review and meta-analysis. Wideochir. Inne Tech. Maloinwazyjne. 2020; 15(3): 403-15. https://dx.doi.org10.5114/wiitm.2020.93791
12. Weigel G.M., Baison G.N., Mihalov L., Mupombwa T. Prevalence of and risk factors for endometrial polyps among asymptomatic postmenopausal women with uterovaginal prolapse. Am. J. Obstet. Gynecol. 2025; 232(2): 196.e1-6. https://dx.doi.org/10.1016/j.ajog.2024.08.001
13. Heremans R., Van Den Bosch T., Valentin L., Wynants L., Pascual M.A., Fruscio R. et al. Ultrasound features of endometrial pathology in women without abnormal uterine bleeding: results from the International endometrial tumor analysis study (IETA3). Ultrasound Obstet. Gynecol. 2022; 60(2): 243-55. https://dx.doi.org/ 10.1002/uog.24910
14. Jang S., Hwang S.O. The risk factors for premalignant and malignant endometrial polyps in premenopausal and postmenopausal women and trends over the past decade: a retrospective study in a single center, South Korea. Eur. J. Obstet. Gynecol. Reprod. Biol. 2024; 295: 118-23. https://dx.doi.org/10.1016/j.ejogrb.2024.01.033
15. Wong M., Thanatsis N., Nardelli F., Amin T., Jurkovic D. Risk of pre-malignancy or malignancy in postmenopausal endometrial polyps: A CHAID decision tree analysis. Diagnostics (Basel). 2021; 11(6): 1094. https://dx.doi.org/10.3390/diagnostics11061094
16. Rouholamin S., Irannezhad P., Hashemi M. Comparison of endometrial polyp characteristics in transvaginal sonography and hysteroscopy in predicting endometrial malignancies in premenopausal and postmenopausal women. Adv. Biomed. Res. 2024; 13: 27. https://dx.doi.org/10.4103/abr.abr_264_21
17. Tekin S., Ocal A., Sisman E., Bilginer C., Cetin A. Histological assessment of endometrial polyps resected by hysteroscopy. Eur. Rev. Med. Pharmacol. Sci. 2024; 28(8): 3241-50. https://dx.doi.org/10.26355/eurrev_202404_36052
18. Sasaki L., Andrade K., Figueiredo A., Wanderley M., Pereira M. Factors associated with malignancy in hysteroscopically resected endometrial polyps: a systematic review and meta-analysis. J. Minim. Invasive Gynecol. 2018; 25(5): 777-85. https://doi.org/10.1016/j.jmig.2018.02.004
19. Jacobs I., Tibosch R., Geomini P., Coppus S., Bongers M.Y., van Hanegem N. Atypical endometrial polyps and the incidence of endometrial cancer: a retrospective cohort study. BJOG. 2020; 127(8): 994-9. https://dx.doi.org/10.1111/1471-0528.16194
20. Karakaya B.K., Ozkan N.T., Kansu-Celik H. Malignancy risk of endometrial polyps among geriatric women. Int. J. Gerontol. 2018; 12(3): 215-7. https://doi.org/10.1016/j.ijge.2018.02.013
21. Namazov A., Gemer O., Ben-Arie A., Israeli O., Bart O., Saphier O. Endometrial polyp size and the risk of malignancy in asymptomatic postmenopausal women. J. Obstet. Gynaecol. Can. 2019; 41(7): 912-95. https://dx.doi.org/10.1016/j.jogc.2018.07.019
22. Клинышкова Т.В., Фролова Н.Б., Церцанова Е.А., Чернышова Н.П. Предраковые и злокачественные заболевания эндометрия у пациенток с эндометриальными полипами в постменопаузе. Лечащий врач. 2025; 5(28): 27-31.
23. Ghoubara A., Sundar S., Ewies A. Predictors of malignancy in endometrial polyps: study of 421 women with postmenopausal bleeding. Climacteric. 2018; 21(1): 82-7. https://dx.doi.org/10.1080/13697137.2017.1410783
24. Meng Q., Ge N., Fan Y., Li L. Analysis of ultrasonic imaging changes and factors related to malignant transformation in postmenopausal patients with endometrial polyps. Am. J. Transl. Res. 2024; 16(7): 3055-63. https://dx.doi.org/10.62347/GFIU8015
25. Cetin F., Kayar İ., Birge Ö., Goc G. Malignancy risk factors based on endometrial polyp. BMC Womens Health. 2024; 24(1): 567. https://dx.doi.org/10.1186/s12905-024-03406-3
26. Capmas P., Pourcelot A.-G., Giral E., Fedida D., Fernandez H. Office hysteroscopy: a report of 2402 cases. J. Gynecol. Obstet. Biol. Reprod. (Paris). 2016; 45(5): 445-50. https://dx.doi.org/10.1016/j.jgyn.2016.02.007
27. Lee S.C., Kaunitz A.M., Sanchez-Ramos L., Rhatigan R.M. The oncogenic potential of endometrial polyps: a systematic review and meta-analysis. Obstet. Gynecol. 2010; 116: 1197-205. https://dx.doi.org/10.1097/AOG.0b013e3181f74864
28. Assem H. Endometrial polyp in postmenopausal women: an epicenter for the development of endometrial serous carcinoma. Arch. Pathol. Lab. Med. 2023; 147(4): 413-7. https://dx.doi.org/: 10.5858/arpa.2021-0557-RA
29. Yadav S., Agarwal A., Mokal S., Menon S., Rekhi B., Deodhar K. Serous endometrial intraepithelial carcinoma: a clinico-pathological study of 48 cases and its association with endometrial polyps – a tertiary care oncology centre experience. Eur. J. Obstet. Gynecol. Reprod. Biol. 2021; 264: 168-72. https://dx.doi.org/: 10.1016/j.ejogrb.2021.07.007
30. Assem H., Rottmann D., Finkelstein A., Wang M., Ratner E., Santin A.D. et al. Minimal uterine serous carcinoma and endometrial polyp: a close clinicopathological relationship. Hum. Pathol. 2021; 118: 1-8. https://dx.doi.org/10.1016/j.humpath.2021.09.001
31. Yin X., Cheng J., Ansari S.H., Campo R., Di W., Li W., Bigatti G. Hysteroscopic tissue removal systems for the treatment of intrauterine pathology: a systematic review and meta-analysis. Facts Views Vis. Obgyn. 2018; 10(4):207-13.
32. Wang Y., Cao X., Fan X., Zhu P. Clinical efficacy study of the IBS® (Intergrated Bigatti Shaver) Tissue Removal Device in the treatment of endometrial polyps. World J. Surg. Oncol. 2024; 22(1): 321. https://dx.doi.org/10.1186/s12957-024-03605-0
33. Timmerman S., Kerrebroeck H.V., Ledger A., Dewilde K., Severen R.V., den Bosch T.V. et al. The use of the 19Fr. Intrauterine BIGATTI Shaver in operative hysteroscopy for benign intracavitary lesions: a feasibility study. Eur. J. Obstet. Gynecol. Reprod. Biol. 2025; 307: 197-202. https://dx.doi.org/10.1016/j.ejogrb.2025.02.005
34. Sivas M.C., Ohanoglu Cetinel K., Arslan H.S. Evaluation of whether there is residual polyp tissue after hysteroscopic morcellation at Cam and Sakura City Hospital: a retrospective cohort study. BMC Womens Health. 2024; 24(1): 133. https://dx.doi.org/10.1186/s12905-024-02978-4
35. Hiratsuka D., Tsuchiya A., Fujimoto A., Nishii O. Anesthesia-free in-office hysteroscopic morcellation for endometrial polyps: a prospective study. Gynecol. Minim. Invasive Ther. 2024; 13(3): 174-9. https://dx.doi.org/10.4103/gmit.gmit_64_23
36. Nijkang N.P., Anderson L., Markham R., Manconi F. Endometrial polyps: pathogenesis, sequelae and treatment. SAGE Open Med. 2019; 7: 2050312119848247. https://dx.doi.org/10.1177/2050312119848247
37. Vitale S.G., Haimovich S., Laganà A.S., Alonso L., Di Spiezio Sardo A., Carugno J. Endometrial polyps. An evidence-based diagnosis and management guide. Eur. J. Obstet. Gynecol. Reprod. Biol. 2021; 260: 70-7. https://dx.doi.org/ 10.1016/j.ejogrb.2021.03.017
38. American Association of Gynecologic Laparoscopists. AAGL practice report: practice guidelines for the diagnosis and management of endometrial polyps. J. Minim. Invasive Gynecol. 2012; 19(1): 3-10. https://dx.doi.org/10.1016/j.jmig.2011.09.003
39. Famuyide A.O., Breitkopf D.M., Hopkins M.R., Laughlin-Tommaso S.K. Asymptomatic thickened endometrium in postmenopausal women: malignancy risk. J. Minim. Invasive Gynecol. 2014; 21(5): 782-6. https://dx.doi.org/ 10.1016/j.jmig.2014.03.004
40. Bougie O., Randle E., Thurston J., Magee B., Warshafsky C., Rittenberg D. Guideline No. 447: diagnosis and management of endometrial polyps. J. Obstet. Gynaecol. Can. 2024; 46(3): 102402. https://dx.doi.org/10.1016/j.jogc.2024.102402
41. Wolfman W., Bougie O., Chen I., Tang Y., Goldstein S., Bouteaud J. Guideline No. 451: asymptomatic endometrial thickening in postmenopausal women. J. Obstet. Gynaecol. Can. 2024; 46(7): 102591. https://dx.doi.org/10.1016/j.jogc.2024.102591
42. Министерство здравоохранения Российской Федерации. Клинические рекомендации. Полипы эндометрия. М.; 2023. 17 c.

Поступила 27.06.2025

Принята в печать 01.11.2025