Андрогеновый статус у пациенток в программах ЭКО

1. Walters K.A. Role of androgens in normal and pathological ovarian function. Reproduction. 2015; 149(4): R193-218.
2. Labrie F., Martel C., Bélanger A., Pelletier G. Androgens in women are essentially made from DHEA in each peripheral tissue according to intracrinology. J. Steroid Biochem. Mol. Biol. 2017; 168: 9-18.
3. Sunkara S.K., Rittenberg V., Raine-Fenning N., Bhattacharya S., Zamora J., Coomarasamy A. Association between the number of eggs and live birth in IVF treatment: an analysis of 400 135 treatment cycles. Hum. Reprod. 2011; 26(7): 1768-74.
4. Nagels H.E., Rishworth J.R., Siristatidis C.S., Kroon B. Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction. Cochrane Database Syst. Rev. 2015; (11): CD009749.
5. Sunkara S.K., Coomarasamy A., Arlt W., Bhattacharya S. Should androgen supplementation be used for poor ovarian response in IVF? Hum. Reprod. 2012; 27(3): 637-40.
6. Gleicher N., Kim A., Weghofer A., Kushnir V.A., Shohat-Tal A., Lazzaroni E. et al. Hypoandrogenism in association with diminished functional ovarian reserve. Hum. Reprod. 2013; 28(4): 1084-91.
7. Gleicher N., Weghofer A., Barad D.H. The role of androgens in follicle maturation and ovulation induction: friend or foe of infertility treatment? Reprod. Biol. Endocrinol. 2011; 9: 116.
8. Prizant H., Gleicher N., Sen A. Androgens actions in the ovary: balance is key. J. Endocrinol. 2014; 222(3): R141-52.
9. Barad D.H., Kushnir V.A., Lee H.J., Lazzaroni E., Gleicher N. Effect of inter-cycle interval on oocyte production in humans in the presence of the weak androgen DHEA and follicle stimulating hormone: a case-control study. Reprod. Biol. Endocrinol. 2014; 12: 68.
10. Teubel J., Wüst B., Schipke C.G., Peters O., Parr M.K. Methods in endogenous steroid profiling - A comparison of gas chromatography mass spectrometry (GC-MS) with supercritical fluid chromatography tandem mass spectrometry (SFC-MS/MS). J. Chromatogr. A. 2018; 1554: 101-16.
11. Gleicher N., Kushnir V.A., Barad D.H. Impact of androgen supplementation on the follicular endocrine milieu in women with hypoandrogenism. Reprod. Biomed. Online. 2018; 36(6): 719-20.
12. Qin Y., Zhao Z., Sun M., Geng L., Che L., Chen Z.J. Association of basal serum testosterone levels with ovarian response and in vitro fertilization outcome. Reprod. Biol. Endocrinol. 2011; 9: 9.
13. Lu Q., Shen H., Li Y., Zhang C., Wang C., Chen X. et al. Low testosterone levels in women with diminished ovarian reserve impair embryo implantation rate: a retrospective case-control study. J. Assist. Reprod. Genet. 2014; 31(4): 485-91.
14. Xiao S., Li Y., Long L., Luo C., Mai Q. Basal serum testosterone levels correlate with ovarian reserve and ovarian response in cycling women undergoing in vitro fertilization. Gynecol. Endocrinol. 2016; 32(1): 51-4.
15. Крстич Е.В., Краснополольская К.В., Кабанова Д.И. Новые подходы к повышению эффективности ЭКО у женщин старшего репродуктивного возраста. Акушерство и гинекология. 2010; 2: 48-53.
16. Abide Yayla C., Ozkaya E., Kayatas Eser S., Sanverdi I., Devranoglu B., Kutlu T. Association of basal serum androgen levels with ovarian response and ICSI cycle outcome. Ir. J. Med. Sci. 2018; 187(2): 409-15.
17. Гончаров Н.П., Дедов И.И., Кация Г.В., Гависова А.А., Сухих Г.Т. Особенности метаболизма дегидроэпиандростерона и современные возможности его использования для коррекции нарушений репродуктивной функции. Акушерство и гинекология. 2017; 7: 18-26.
18. Shohat-Tal A., Sen A., Barad D.H., Kushnir V., Gleicher N. Genetics of androgen metabolism in women with infertility and hypoandrogenism. Nat. Rev. Endocrinol. 2015: 11(7): 429-41.
19. Triantafyllidou O., Sigalos G., Vlahos N. Dehydroepiandrosterone (DHEA) supplementation and IVF outcome in poor responders. Hum. Fertil. (Camb.). 2017; 20(2): 80-7.
20. Nardo L.G., El-Toukhy T., Stewart J., Balen A.H., Potdar N. British Fertility Society Policy and Practice Committee: adjuvants in IVF: evidence for good clinical practice. Hum. Fertil. 2015; 18: 2-15.
21. Zhang M., Niu W., Wang Y., Xu J., Bao X., Wang L. et al. Dehydroepiandrosterone treatment in women with poor ovarian response undergoing IVF or ICSI: a systematic review and meta-analysis. J. Assist. Reprod. Genet. 2016; 33(8): 981-91.
22. Kotb M.M.M., Hassan A.M.A., Awadallah A.M.A. Does dehydroepiandrosterone improve pregnancy rate in women undergoing IVF/ICSI with expected poor ovarian response according to the Bologna criteria? A randomized controlled trial. Eur. J. Obstet. Gynecol. Reprod. Biol. 2016; 200: 11-5.
23. Zhang H.H., Xu P.Y., Wu J., Zou W.W., Xu X.M., Cao X.Y. et al. Dehydroepiandrosterone improves follicular fluid bone morphogenetic protein15 and accumulated embryo score of infertility patients with diminished ovarian reserve undergoing in vitro fertilization: a randomized controlled trial. J. Ovarian Res. 2014; 7: 93.
24. Yeung T.W.Y., Chai J., Li R.H.W., Lee V.C.Y., Ho P.C., Ng E.H.Y. A double-blind randomised controlled trial on the effect of dehydroepiandrosterone on ovarian reserve markers, ovarian response and number of oocytes in anticipated normal ovarian responders. BJOG. 2016; 123(7): 1097-105.
25. Keane K.N., Hinchliffe P.M., Rowlands P.K., Borude G., Srinivasan S., Dhaliwal S.S., Yovich J.L. DHEA supplementation confers no additional benefit to that of growth hormone on pregnancy and live birth rates in IVF patients categorized as poor prognosis. Front. Endocrinol. (Lausanne). 2018; 9: 14.
26. Qin J.C., Fan L., Qin A.P. The effect of dehydroepiandrosterone (DHEA) supplementation on women with diminished ovarian reserve (DOR) in IVF cycle: evidence from a meta-analysis. J. Gynecol. Obstet. Hum. Reprod. 2017; 46(1): 1-7.
27. Hu Q., Hong L., Nie M., Wang Q., Fang Y., Dai Y. et al. The effect of dehydroepiandrosterone supplementation on ovarian response is associated with androgen receptor in diminished ovarian reserve women. J Ovarian Res. 2017; 10(1): 32.
28. Sen A., Prizant H., Light A., Biswas A., Hayes E., Lee H.J. et al. Androgens regulate ovarian follicular development by increasing follicle stimulating hormone receptor and microRNA-125b expression. Proc. Natl. Acad. Sci. USA. 2014; 111(8): 3008-13.
29. Li M., Schatten H., Sun Q.Y. Androgen receptor’s destiny in mammalian oocytes: a new hypothesis. Mol. Hum. Reprod. 2009; 15(3): 149-54.
30. Borgbo T., Macek M. Sr., Chrudimska J., Jeppesen J.V., Hansen L.L., Andersen C.Y. Size matters: Associations between the androgen receptor CAG repeat length and the intrafollicular hormone milieu, Mol. Cell. Endocrinol. 2016; 419: 12-7.
31. Lledó B., Llácer J., Turienzo A., Ortiz J.A., Guerrero J., Morales R. et al. Androgen receptor CAG repeat length is associated with ovarian reserve but not with ovarian response. Reprod. Biomed. Online. 2014; 29(4): 509-15.

Поступила 22.08.2018

Принята в печать 21.09.2018