Role of genetically determined fetal hemostatic disorders in the development of severe forms of placental insufficiency
Objective. To study the specific features of development of genetically determined fetal hemostatic disorders and their role in the genesis of severe forms of placental insufficiency.Nesterova E.A., Putilova N.V., Tretyakova T.B., Pestryaeva L.A.
Subjects and methods. Seventy married couples and their newborns underwent clinical and laboratory examinations and constituted two groups: a study group (n = 50), in which their pregnancy was complicated by sub- or decompensated forms of placental insufficiency, and a control group (n = 20) without a compromised obstetric history, with current physiological pregnancy. The polymorphic variants of the genes involved in blood aggregation and folate metabolism were investigated by real-time polymerase chain reaction; the blood coagulation system was evaluated in women and babies.
Results. The women in the study group were found to have statistically significant differences in the frequency of polymorphic variants of the genes: PAI-1, ITGB3, F7, F13, and MTHFR; the men in this group had PAI-1, ITGA2 807; their newborn babies had PAI-1 and MTHFR. In addition, in the study group the women and babies were detected to have the clotting disorders indicating the activation of intravascular microcoagulation.
Conclusion. Clinically significant fetal thrombophilia makes a considerable contribution to the development of severe forms of placental insufficiency.
Keywords
placental insufficiency
inherited thrombophilia
neonatal hemostasis
thromboelastography
Supplementary Materials
- Table 1. Comparative characteristics of hemostasis parameters in pregnant women оf the primary and control groups of study, (M ± m)
- Table 2. Comparative characteristics of hemostasis parameters in newborns of the primary and control groups, (M ± m)
- Picture. Polymorphisms of thrombophilia genes that have significantly significant differences in the frequency of occurrence in the study groups
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Received 15.12.2016
Accepted 23.12.2016
About the Authors
Nesterova Elvira Agzamovna, intramural post-graduate student, Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia.620028, Russia, Ekaterinburg, Repina str. 1. E-mail: elvira.nesterova.85@mail.ru
Putilova Natalia Viktorovna, MD, Head of the Department of antenatal protection of the fetus, Ural Research Institute of Maternal and Infant Care,
Ministry of Health of Russia. 620028, Russia, Ekaterinburg, Repina str. 1. Tel.: +73433715240. E-mail: putilova-1959@mail.ru
Tretyakova Tatyana Borisovna, PhD, a senior researcher at the Department of biochemical methods of investigation, Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia. 620028, Russia, Ekaterinburg, Repina str. 1. Tel.: +73433598190. E-mail: 79122467716@ya.ru
Pestryaeva Lyudmila Anatolevna, PhD, head of research department of biochemical methods of investigation, Ural Research Institute of Maternal and Infant Care,
Ministry of Health of Russia. 620028, Russia, Ekaterinburg, Repina str. 1. Tel.: +73433598190. E-mail: pestryaeval@yandex.ru
For citations: Nesterova E.A., Putilova N.V., Tretyakova T.B., Pestryaeva L.A. Role of genetically determined fetal hemostatic disorders in the development of severe forms of placental insufficiency. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (9): 58-62. (in Russian)
http://dx.doi.org/10.18565/aig.2017.9.58-62
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