Возможности реализации репродуктивной функции у больных раком молочной железы
Оганян К.А., Перминова С.Г., Митюрина Е.В., Родионова М.В.
Рак молочной железы (РМЖ) остается наиболее распространенным онкологическим заболеванием у женщин репродуктивного возраста, что делает сохранение фертильности и последующую реализацию репродуктивной функции клинически значимыми задачами. В обзоре представлены дискуссионные вопросы влияния различных схем полихимиотерапии на овариальный резерв, обсуждаются различные методы сохранения фертильности у больных РМЖ. Особое внимание уделено современным протоколам стимуляции (random-start, DuoStim) с добавлением ингибиторов ароматазы и антиэстрогенов у пациенток с гормон-чувствительным РМЖ. Рассмотрены противоречивые данные о влиянии герминальных мутаций на овариальный резерв. Ключевое место отведено методам реализации репродуктивной функции после завершения химиотерапии в зависимости от сохранения/утраты функции яичников.
Заключение. Криоконсервация ооцитов и эмбрионов остается золотым стандартом онкофертильности. Перспективы дальнейших исследований включают изучение влияния новых классов противоопухолевых препаратов на овариальный резерв и исходы беременности, оценку долгосрочной безопасности прерывания эндокринотерапии у пациенток с высоким риском рецидива, а также валидацию генетических маркеров преждевременной недостаточности яичников для более точного прогнозирования индивидуального риска и выбора оптимальной стратегии сохранения фертильности.
Вклад авторов. Оганян К.А. – поиск и анализ литературы, обработка исходного материала, написание текста рукописи; Перминова С.Г., Митюрина Е.В., Родионова М.В. – разработка концепции статьи, анализ данных литературы, редактирование.
Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов. Финансирование данной работы не проводилось.
Генеративный искусственный интеллект. При создании данной статьи технологии генеративного искусственного интеллекта не использовали.
Для цитирования: Оганян К.А., Перминова С.Г., Митюрина Е.В., Родионова М.В. Возможности реализации репродуктивной функции у больных раком молочной железы.
Акушерство и гинекология. 2026; 10: 46-54
https://dx.doi.org/10.18565/aig.2026.177
Ключевые слова
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Поступила 08.06.2026
Принята в печать 15.09.2026
Об авторах / Для корреспонденции
Оганян Карина Амбарцумовна, аспирант, Научно-клиническое отделение ВРТ им. Ф. Паулсена, Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова Минздрава России, 117997, Россия, Москва, ул. Акад. Опарина, д. 4, oganyan_karina@bk.ru,https://orcid.org/0000-0002-2743-0882
Перминова Светлана Григорьевна, д.м.н., в.н.с., Научно-клиническое отделение ВРТ им. Ф. Паулсена, Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова Минздрава России, 117997, Россия, Москва, ул. Акад. Опарина, д. 4, s_perminova@oparina4.ru,
https://orcid.org/0000-0003-4438-1354
Митюрина Елена Викторовна, д.м.н., с.н.с., Научно-клиническое отделение ВРТ им. Ф. Паулсена, Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова Минздрава России, 117997, Россия, Москва, ул. Акад. Опарина, д. 4, e_miturina@oparina4.ru,
https://orcid.org/0000-0001-8830-2158
Родионова Мария Валерьевна, к.м.н., врач-онколог отделения патологии молочной железы, Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова Минздрава России, 117997, Россия, Москва, ул. Акад. Опарина, д. 4, m_rodionova@oparina4.ru,
https://orcid.org/0000-0003-1540-5644
Автор, ответственный за переписку: Карина Амбарцумовна Оганян, oganyan_karina@bk.ru



