ISSN 0300-9092 (Print)
ISSN 2412-5679 (Online)

Вульварные интраэпителиальные неоплазии. Клинические рекомендации

Для цитирования: Вульварные интраэпителиальные неоплазии. Клинические рекомендации.

Акушерство и гинекология. 2025; 7 (Приложение)
https://dx.doi.org/10.18565/aig.2025.178

Кодирование по Международной статистической классификации болезней и проблем, связанных со здоровьем: N90.0-90.3, N84.3, N90.4, N90.6, N90.7, N90.8

Возрастная группа: Взрослые и дети

Год утверждения: 2025

Разработчик клинической рекомендации: ООО «Российское общество акушеров-гинекологов (РОАГ)»

Список литературы

1 - Committee Opinion No.675: Management of Vulvar Intraepithelial Neoplasia. Obstet Gynecol. 2016 Oct;128(4):e178-e182. doi: 10.1097/AOG.0000000000001713. Erratum in: Obstet Gynecol. 2017 Jan;129(1):209. doi: 10.1097/AOG.0000000000001839. PMID: 27661656.

2 - WHO Classification of Tumours Editorial Board. Female genital tumours. 5th ed. Lyon; 2020. https://tumourclassification.iarc.who.int/chapters/34

3 - Pils S, Gensthaler L, Alemany L, Horvat R, de Sanjose S, Joura EA. HPV prevalence in vulvar cancer in Austria. Wiener klinischeWochenschrift. 2017; 129: 805-809. doi: 10.1007/s00508-017-1255-2,

4 - Wakeham K, Kavanagh K, Cuschieri K, Millan D, Pollock KG, Bell S, et al. HPV status and favourable outcome in vulvar squamous cancer. IntJ Cancer. 2017; 140(5): 1134-1146. doi: 10.1002/ijc.30523

5 - Roy SF, Wong J, Le Page C, Tran-Thanh D, Barkati M, Pina A, Trinh VQ, Rahimi K. DEVIL, VAAD and vLSC constitute a spectrum of HPV-independent, p53-independent intra-epithelial neoplasia of the vulva. Histopathology. 2021 Dec;79(6):975-988. doi: 10.1111/his.14451. Epub 2021 Sep 20. PMID: 34265101.

6 - Day T, Marzol A, Pagano R, Jaaback K, Scurry J. Clinicopathologic diagnosis of vulvar intraepithelial neoplasia and vulvar aberrant maturation. J Lower Genit Tract Dis. 2020; 24(4): 317-329.doi: 10.1097/LGT.0000000000000569;

7 - Nascimento AF, Granter SR, Cviko A, Yuan L, Hecht JL,Crum CP. Vulvar acanthosis with altered differentiation: A precursor to verrucous carcinoma? Am J Surg Pathol. 2004; 28(5):638-643.doi: 10.1097/00000478-200405000-00012

8 - Preti M, Joura E, Vieira-Baptista P, Van Beurden M, Bevilacqua F, Bleeker MCG, Bornstein J, Carcopino X, Chargari C, Cruickshank ME, Erzeneoglu BE, Gallio N, Heller D, Kesic V, Reich O, Stockdale CK, Temiz BE, Woelber L, Planchamp F, Zodzika J, Querleu D, Gultekin M. The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD) and the European Federation for Colposcopy (EFC) Consensus Statements on Pre-invasive Vulvar Lesions. J Low Genit Tract Dis. 2022 Jul 1;26(3):229-244. doi: 0.1097/LGT.0000000000000683. Epub 2022 Jun 21. PMID: 35763611; PMCID: PMC9232287.

9 - Van der Meijden WI, Boffa MJ, Ter Harmsel B, Kirtschig G, Lewis F, Moyal-Barracco M, Tiplica GS, Sherrard J. 2021 European guideline for the management of vulval conditions. J Eur Acad Dermatol Venereol. 2022 Jul;36(7):952-972. doi: 10.1111/jdv.18102. Epub 2022 Apr 12. PMID: 35411963.

10 - Oonk MHM, Planchamp F, Baldwin P, Mahner S, Mirza MR, Fischerová D, Creutzberg CL, Guillot E, Garganese G, Lax S, Redondo A, Sturdza A, Taylor A, Ulrikh E, Vandecaveye V, van der Zee A, Wölber L, Zach D, Zannoni GF, Zapardiel I. European Society of Gynaecological Oncology Guidelines for the Management of Patients with Vulvar Cancer - Update 2023. Int J Gynecol Cancer. 2023 Jul 3;33(7):1023-1043. doi: 10.1136/ijgc-2023-004486. PMID: 37369376; PMCID: PMC10359596.

11 - M. Lebreton, I. Carton, S. Brousse, V. Lavoué, G. Body, J. Levêque, K. Nyangoh-Timoh,Vulvar intraepithelial neoplasia: Classification, epidemiology, diagnosis, and management,Journal of Gynecology Obstetrics and Human Reproduction,Volume 49, Issue 9,2020, https://doi.org/10.1016/j.jogoh.2020.101801

12 - Pagan L, Ederveen RAM, Huisman BW, Schoones JW, Zwittink RD, Schuren FHJ, Rissmann R, Piek JMJ, van Poelgeest MIE. The Human Vulvar Microbiome: A Systematic Review. Microorganisms. 2021 Dec 12;9(12):2568. doi: 10.3390/microorganisms9122568. PMID: 34946169; PMCID: PMC8705571.]

13 - Rustetska N, Szczepaniak M, Goryca K, Bakuła-Zalewska E, Figat M, Kowalik A, Góźdź S, Kowalewska M. The intratumour microbiota and neutrophilic inflammation in squamous cell vulvar carcinoma microenvironment. J Transl Med. 2023 Apr 28;21(1):285. doi: 10.1186/s12967-023-04113-7

14 - Hoang LN, Park KJ, Soslow RA, Murali R. Squamous precursor lesions of the vulva: Current classification and diagnostic challenges. Pathology. 2016; 48(4): 291-302. doi: 10.1016/j.pathol.2016.02.015,

15 - Cohen PA, Anderson L, Eva L, Scurry J. Clinical and molecular classification of vulvar squamous pre-cancers. IntJ Gynecol Cancer. 2019; 29(4): 821-828. doi: 10.1136/ijgc-2018-000135

16- Brzeziński, M.; Stukan, M. Anal Cancer and Anal Intraepithelial Neoplasia Risk among Patients Treated for HPV-Related Gynecological Diseases—A Systematic Review. J. Clin. Med. 2023, 12, 4216. https://doi.org/10.3390/jcm12134216 ]

17 - Henderson I, Lewis F, Williams A, Yap J, Krishna A. The diagnosis and management of vulval intraepithelial neoplasia. TheObstetrician & Gynaecologist 2024;26:18–26. https://doi.org/10.1111/tog.12906

18 - Kesi´c, V.; Vieira-Baptista, P.; Stockdale, C.K. Early Diagnostics of Vulvar Intraepithelial Neoplasia. Cancers 2022, 14, 1822. https:// doi.org/10.3390/cancers14071822

19 - Preventive Oncology for the Gynecologist Sumita Mehta, Anshuja Singla Springer Nature Singapore Pte Ltd. 2019 https://doi.org/10.1007/978-981-13-3438-2]

20 - Cohen PA, Anderson L, Eva L, Scurry J. Clinical and molecular classification of vulvar squamous pre-cancers. IntJ Gynecol Cancer. 2019; 29(4): 821-828. doi: 10.1136/ijgc-2018-000135

21 - Hoang LN, Park KJ, Soslow RA, Murali R. Squamous precursor lesions of the vulva: Current classification and diagnostic challenges. Pathology. 2016; 48(4): 291-302. doi: 10.1016/j.pathol.2016.02.015;

22 - Jin C, Liang S. Differentiated vulvar intraepithelial neoplasia: A brief review of clinicopathologic features. Arch PatholLab Med. 2019; 143(6): 768-771. doi: 10.5858/arpa.2018-0019-RS.

23 - Watkins JC, Howitt BE, Horowitz NS, Ritterhouse LL, Dong F, MacConaill LE, et al. Differentiated exophytic vulvar intraepithelial lesions are genetically distinct from keratinizing squamous cell carcinomas and contain mutations in PIK3CA. Mod Pathol. 2017; 30(3): 448-458. doi: 10.1038/modpathol.2016.187

24 - Parra-Herran C, Nucci MR, Singh N, Rakislova N, Howitt BE, Hoang L, Gilks CB, Bosse T, Watkins JC. HPV-independent, p53-wild-type vulvar intraepithelial neoplasia: a review of nomenclature and the journey to characterize verruciform and acanthotic precursor lesions of the vulva. Mod Pathol. 2022 Oct;35(10):1317-1326. doi: 10.1038/s41379-022-01079-7.

25 - Heller DS Day T Allbritton JI, et al.. Diagnostic criteria for differentiated vulvar intraepithelial neoplasia and vulvar aberrant maturation. J Low Genit Tract Dis 2021;25:57–70 ,

26 - Клинические рекомендации Цервикальная интраэпителиальная неоплазия, эрозия и эктропион шейки матки, 2024

27 - Zhang L, Hemminki O, Chen T, Zheng G, Försti A, Sundquist K, Sundquist J, Hemminki K. Familial Clustering, Second Primary Cancers and Causes of Death in Penile, Vulvar and Vaginal Cancers. Sci Rep. 2019 Aug 14;9(1):11804. doi: 10.1038/s41598-019-48399-4. PMID: 31413311; PMCID: PMC6694134.

28 - Lee A, Bradford J, Fischer G. Long-term management of adult vulvar lichen sclerosus: a prospective cohort study of 507 women. JAMA Dermatol 2015;151:1061–7.

29 - Inayama Y, Yamanishi Y, Nakatani E, Aratake J, Sasagasako N, Yamada K, Gou R, Kawamura A, Yamanishi M, Kosaka K. Imiquimod for vaginal intraepithelial neoplasia 2-3: A systematic review and meta-analysis. Gynecol Oncol. 2021 Jan;160(1):140-147. doi: 10.1016/j.ygyno.2020.09.031. Epub 2020 Oct 1. PMID: 33010966.

30 - Lawrie TA, Nordin A, Chakrabarti M, Bryant A, Kaushik S, Pepas L. Medical and surgical interventions for the treatment of usual-type vulval intraepithelial neoplasia. Cochrane Database of Systematic Reviews 2016, Issue 1. Art. No.: CD011837. DOI: 10.1002/14651858.CD011837.pub2

31 - Comprehensive Cervical Cancer Control: A Guide to Essential Practice. 2nd ed. Geneva: World Health Organization; 2014.

32 - Kew F. M., Cruickshank D. J. Routine follow-up after treatment for a gynecological cancer: a survey of practice //International Journal of Gynecologic Cancer. – 2006. – Т. 16. – №. 1. – С. 380-384. .

33 - Минкина Г. Н. и др. Постлечебный мониторинг цервикальных интраэпителиальных неоплазий //Журнал акушерства и женских болезней. – 2011. – Т. 60. – №. 1. .

34 - Meijer C. et al. Validation of high-risk HPV tests for primary cervical screening //Journal of Clinical Virology. – 2009. – Т. 46. – С. S1-S4. .

35 - Poljak M et al. Commercially available molecular tests for human papillomaviruses: a global overview. Clin Microbiol Infect. 2020. .

36 - Вакцины против папилломавирусной инфекции человека: документ по позиции ВОЗ., no. 43. 2014.

37 - Баранов А. А. и др. Вакцинопрофилактика заболеваний, вызванных вирусом папилломы человека: позиции доказательной медицины. Обзор клинических рекомендаций //Вопросы современной педиатрии. – 2017. – Т. 16. – №. 2. .

38 - National Advisory Committee on Immunization (NACI) et al. Updated Recommendations on Human Papillomavirus (HPV) Vaccines: 9-valent HPV vaccine 2-dose immunization schedule and the use of HPV vaccines in immunocompromised population. 2017. Ottawa //ON: Pub. .

39 - ACOG. Committee Opinion No. 704: Human Papillomavirus Vaccination., vol. 129, no. 6. 2017.

40 - Global Advisory Committee on Vaccine Safety - 4–5 December 2019. WHO. Weekly epidemiological record No 4, 2020.

41 - Parra-Herran C, Nucci MR, Singh N, Rakislova N, Howitt BE, Hoang L, Gilks CB, Bosse T, Watkins JC. HPV-independent, p53-wild-type vulvar intraepithelial neoplasia: a review of nomenclature and the journey to characterize verruciform and acanthotic precursor lesions of the vulva. Mod Pathol. 2022 Oct;35(10):1317-1326. doi: 10.1038/s41379-022-01079-7. Epub 2022 Apr 18. PMID: 35437330.

42 - Abu-Rustum N. R. et al. Vulvar Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology //Journal of the National Comprehensive Cancer Network. – 2024.

43 - Dennerstein, G. (2009). Vulvar Cytology. Journal of Lower Genital Tract Disease, 13(3), 192.

44 - Стругацкий В.М., Маланова Т.Б., Арсланян К.Н. Физиотерапия в практике акушера-гинеколога (клинические аспекты и рецептура). - 2-е изд. – Москва: МЕДпресс-информ, 2008.

45 - Morrison J, Baldwin P, Buckley L, et al. British Gynaecological Cancer Society (BGCS) vulval cancer guidelines: recommendations for practice. Eur J Obstet Gynecol Reprod Biol. 2020;252:502e525.

Продолжая использовать наш сайт, вы даете согласие на обработку файлов cookie, которые обеспечивают правильную работу сайта.