Increased thrombin generation as a potential marker of adverse pregnancy outcomes

Gribkova I.V., Koroleva N.S., Davydovskaya M.V., Murashko A.V.

1 Center for Clinical Research and Health Technology Assessment of the Moscow Health Department, Moscow, Russia; 2 I.M. Sechenov First Moscow State Medical University of Minzdrav of Russia (Sechenov University), Moscow, Russia; 3 N.I. Pirogov Russian National Research Medical University of Minzdrav of Russia
Aim. To estimate the effectiveness of the thrombin generation assay (TGA) in identifying high thrombogenic risk in pregnant women. Material and methods. The study comprised 30 healthy non-pregnant women (control group) and 32 women in the third trimester of pregnancy. Of the latter group, 22 women with complicated pregnancy comprised the study group while the remaining ten women made up the comparison group. After delivery, the patients in the study group were divided into subgroups with a favorable (n = 15) and adverse (n = 7) pregnancy outcomes. The state of the hemostatic system was examined using standard coagulation tests and TGA. Results. Thrombin generation assessed as endogenous thrombin potential (ETP), was statistically significantly higher in pregnant than in non-pregnant women (2300 ± 400 vs. 1700 ± 400, respectively, p <0.005). The patients with adverse pregnancy outcomes had statistically significantly higher ETP compared with women with favorable outcomes (2700 ± 600 vs. 2300 ± 300, respectively, p <0.005). Conclusion. TGA can be used to predict adverse pregnancy outcomes. Elevated ETP is associated with adverse pregnancy outcomes.

Keywords

complications of pregnancy
thrombin generation assay

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Received 16.11.2017

Accepted 22.12.2017

About the Authors

Gribkova Irina Vladimirovna, Ph.D.(bio.sci.), Leading Researcher at the Scientific and Clinical Department, Center for Clinical Research and Health Technology Assessment
of the Moscow Health Department, Moscow, Russia. Address: 121096, Russia, Moscow, ul. Minskaya, 12, build. 2. Tel.: 8 (499) 144-00-30. E-mail: igribkova@yandex.ru
Koroleva Natal'ya Sergeevna, Ph.D. Student at the Department of Obstetrics and Gynecology No. I.M. Sechenov First MSMU of Minzdrav of Russia (Sechenov University). Address: 119991, Russia, Moscow, ul. Bolshaya Pirogovskaya, 2, page 4. Tel.: 8 (916) 186-73-37. E-mail: tashakoroleva@gmail.com
Davydovskaya M.V., Dr.Med.Sci., Deputy Director for Research, Center for Clinical Research and Health Technology Assessment of the Moscow Health Department, Moscow, Russia; Professor of the Department of Neurology, Neurosurgery and Medical Genetics, N.I. Pirogov RNRMU of Minzdrav of Russia.
Address: 117997, Russia, Moscow, ul. Ostrovityanova, 1. Tel.: 8 (499) 144-00-30. E-mail: mdavydovskaya@gmail.com
Murashko Andrei Vladimirovich, Professor at the Department of Obstetrics and Gynecology No. 1, I.M. Sechenov First MSMU of Minzdrav of Russia (Sechenov University). Address: 119991, Russia, Moscow, ul. Bolshaya Pirogovskaya, 2, page 4. Tel:: 8 (963) 782-02-45. E-mail: murashkoa@mail.ru

For citation: Gribkova I.V., Koroleva N.S., Davydovskaya M.V., Murashko A.V. Increased thrombin generation as a potential marker of adverse pregnancy outcomes. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (8): 92-7. (in Russian)
https://dx.doi.org/10.18565/aig.2018.8.92-97
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