Genetic factors in the development of recurrent miscarriage: An overview of the data of meta-analyses

Trifonova E.A., Ganzha O.A., Gabidulina T.V., Devyatyarova L.L., Sotnikova L.S., Stepanov V.A.

1Research Institute of Medical Genetics, Tomsk Research Medical Center, Tomsk 634050, Embankment of the river Ushayki, 10, Russia 2Siberian State Medical University, Ministry of Health of Russia, Tomsk 634050, Moscow highway, 2, Russia 3Regional Perinatal Center, Tomsk 634049, Ivana Chernykh str. 96/1, Russia
Objective. The review highlights the issues associated with a study of the role of genetic components in recurrent miscarriage (RM) susceptibility through generalized quantitative analysis of data.
Material and methods. The review includes the results of foreign and Russian meta-analyses published in the past 10 years and found in the Pubmed database on this topic.
Results. The data obtained from the meta-analyses of studies of an association of allelic variants of candidate genes with RM were generalized and the functional significance of a number of associated polymorphic markers was characterized. Consideration of the ethnicity of individuals was shown to be important in studying the role of genetic factors in the development of this disease, as well as gene-gene and gene-environmental interactions.
Conclusion. Creation of a future database including the results of associative studies with a detailed description of their design (detailed clinical characteristics of the examinees; criteria for group formations; patient ethnicity) will provide statistically significant evidence for the role of genetic components in the structure of RM susceptibility.

Keywords

recurrent miscarriage
polymorphic variant
gene
hereditary predisposition
meta-analysis

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Received 19.08.2016

Accepted 02.09.2016

About the Authors

Trifonova Ekaterina Aleksandrovna, Candidate of Medical Science, Research Associate, Research Institute of Medical Genetics, Tomsk Research Medical Center.
634050, Russia, Tomsk, Embankment of the river Ushayki, 10. Tel.: +73822513334. E-mail: ekaterina.trifonova@medgenetics.ru
Ganzha Olga Aleksandrovna, a resident of the State Public Health Service of the Siberian State Medical University, Ministry of Health of Russia.
634050, Russia, Tomsk, Moscow highway, 2. Tel.: +79234227446. E-mail: ganzha.olga42@gmail.com
Gabidulina Tatyana Vasilievna, MD, associate professor of the obstetrics and gynecology department, o Siberian State Medical University, Ministry of Health of Russia.
634050, Russia, Tomsk, Moscow highway, 2. Tel.: +79138501120. E-mail: helen556@yandex.ru
Devyatyarova Larisa Leonidovna, obstetrician-gynecologist, Regional Perinatal Center.
634049, Russia, Tomsk, Ivana Chernykh str. 96/1. Tel.: +73822644900. E-mail: dev-larisa@yandex.ru
Sotnikova Larisa Stepanovna, MD, Professor of the Department of Obstetrics and Gynecology, Siberian State Medical University, Ministry of Health of Russia.
634050, Russia, Tomsk, Moscow highway, 2. Tel.: +73822901101. E-mail: sotnikova-larisa@mail.ru
Stepanov Vadim Anatolyevich, Doctor of Biological Sciences, Professor, Director of Research Institute of Medical Genetics, Tomsk Research Medical Center.
634050, Russia, Tomsk, Embankment of the river Ushayki, 10. Tel.: +73822513334. E-mail: vadim.stepanov@medgenetics.ru

For citations: Trifonova E.A., Ganzha O.A., Gabidulina T.V., Devyatyarova L.L., Sotnikova L.S., Stepanov V.A. Genetic factors in the development of recurrent miscarriage: An overview of the data of meta-analyses. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (4): 14-20. (in Russian)
http://dx.doi.org/10.18565/aig.2017.4.14-20

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